Clinical Research


The University of Nottingham Health Service is an NIHR CRN East Midlands Research Leadership site.

We have over 10 years experience in delivering NHS research, contributing to its future viability and benefiting our patients.

We have a broad portfolio but at the moment we are focused mainly on vaccine and immunity research and studies looking at ways to improve the mental health of younger people.


Cloudfree study

We are researching a nicotine mouth spray that is aimed at relieving vape cravings. This clinical study is looking to help people quit vaping. The Cloudfree Study is looking at whether an investigational mouth spray, Nicotine Freshmint Mouthspray, may help e-cigarette (‘vape’) users to quit vaping. The study will also look at how safe  the investigational mouth spray is. You or someone you know may be able to take part  if you/they: 

  • are a healthy adult 
  • have been  vaping for at least 3 months 
  • are highly motivated to quit vaping Participants will be assigned to use either the investigational mouth spray or a placebo mouth spray.      

to find out more please contact us on   

RELIEF asthma trial 

The RELIEF trial is looking at whether a combined inhaler is better for treating mild asthma symptoms. Many UK adults  have “mild” asthma, requiring a reliever (blue) inhaler for symptoms with or without, low-dose-inhaled steroid treatment. Blue inhalers provide symptom relief but cannot help inflammation. Increasing use of blue inhalers and decreasing use of preventer (usually brown) inhalers is associated with poorer asthma outcomes. The Global Initiative for Asthma (world-wide asthma recommendations) suggest replacing the first-choice standard blue inhaler for all asthma patients with a combination inhaler containing both reliever and a preventer medicine. Participants will be selected at random to be in either one of two groups for the trial. Both groups will continue to use their preventer inhaler but one group will receive usual care with a blue reliever inhaler (e.g. Ventolin) and the other will receive a combined reliever + preventer inhaler instead (e.g. Symbicort or Fostair). if you are interested in taking part, please  contact us on   

UK minds

We are trying to understand why some people experience problems with their mental and/or cognitive health. The purpose of this study is to collect information and blood samples for genetic, biological, psychological and clinical research. This will allow us to look for genes and other factors which make some people more likely than others to become ill. We hope that our study will improve understanding of these conditions and help find better treatments in the future. If you are happy to take part please contact us on   

Raptor Swab Study

We are doing a research study to compare how accurate different tests are at detecting past or current coronavirus (COVID-19) infection. We will be comparing the results of new rapid tests with standard laboratory tests for COVID-19. 

If this study identifies a good rapid test for COVID-19 it might be useful in the future for helping doctors and nurses give instant advice about self-isolation
which might help block the spread of the virus, or guide treatment which might help people to feel better more quickly.

Success Stories!!

Harmonie trial 

The Harmonie trial that we are part of  has been shown to cut baby hospitalisation by 80%. B

Want to have a say in research? Become a Research Champion!

We are recruiting ~10 Research Champion volunteers to get involved with Research at Cripps Health Centre. This will involved quarterly meetings where we discuss new and upcoming research studies. We want your opinions and thoughts on how to promote research to the general public. 

To sign up please email us on or call us on 0115 846 8888 and ask for the Research Team. 

New to Research? Find out more about what Clinical Research is

Starting Out Guide - Why and how to get involved in research | NIHR

What is Health Research? Online Course - FutureLearn

Be Part of Research Podcasts - Be Part of Research (

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